Cancer Anorexia Nutrtion support

Anorexia

May impact patients' outcome

Cancer-related anorexia - a highly prevalent side effect

Appetite disorders often come with cancer and anorexia is one symptom of the cancer cachexia syndrome.1,2

At the time of diagnosis, a prevalence up to 50–66 % is reported.3 In advanced cancer patients with different primary cancer sites the incidence of anorexia was 66 %.4

Prevalence Anorexia

 

Causes of cancer anorexia are multifactorial1,5,6

  • Antitumor treatments such as chemotherapy or radiotherapy
  • Inflammatory response caused by the tumor
  • Distress and reduced desire to eat due to cancer diagnosis

have a negative effect on appetite.

 

Anorexia may impact patients’ outcome

Anorexia is significantly associated with weight loss

  • Results in reduced caloric intake1,2,7
  • Anorexia is significantly associated with weight loss ≥ 10 % (OR 13.4, p < 0.001)8

Anorexia negatively affects patients’ outcome1,2

  • Negative impacts on patients’ perceptions and quality of life
  • May lead to increased morbidity and mortality

Appetite loss is significantly associated with reduced survival9

Anorexia Supportan Study

Counteract anorexia and weight loss

Guidelines Anorexia

Nutrition intervention is effective

Dietary intervention with high-energy ONS containing high protein levels and omega-3 PUFA during chemotherapy led to

  • decrease in side effects10
  • loss of appetite
  • fatigue
  • neuropathy
  • increased energy and protein intake10
  • improvement in body weight and skeletal muscle mass/lean body mass11-13
  • positive modulation of inflammation markers10,12
  • improvement in quality of life and functional status14

You’d like to know more about 

  • The relationship between the nutritional status and anorexia
  • Multimodal treatment of cancer-related anorexia?

Please download:

 

Fresubin Cachexia Cancer Oncology

Cachexia

Malnutrition & cachexia needs to be detected as early as possible.

Fresubin

Mucositis

Clinically relevant and often dose-limiting side effect of anti cancer therapy.

Fresubin cancer fatigue oncology

Fatigue

Affects more patients for longer time than any other symptom.

References:
1) Laviano A et al. Cancer anorexia: clinical implications, pathogenesis, and therapeutic strategies. Lancet Oncol. 2003;4(11):686-94.
2) Molfino A et al. Contribution of anorexia to tissue wasting in cachexia. Curr Opin Support Palliat Care. 2010;4(4):249-53.
3) Lis CG et al. Can anorexia predict patient satisfaction with quality of life in advanced cancer? Support Care Cancer. 2009;17(2):129-35.
4) Walsh D et al. The symptoms of advanced cancer: relationship to age, gender, and performance status in 1,000 patients. Support Care Cancer. 2000;8(3):175-9.
5) Ezeoke CC, Morley JE. Pathophysiology of anorexia in the cancer cachexia syndrome. J Cachexia Sarcopenia Muscle. 2015;6(4):287-302.
6) Barajas Galindo DE et al. Appetite disorders in cancer patients: Impact on nutritional status and quality of life. Appetite. 2017;114:23-7.
7) Arends J et al. ESPEN guidelines on nutrition in cancer patients. Clin Nutr. 2017;36(1):11-48.
8) Sánchez-Lara K et al. Gastrointestinal symptoms and weight loss in cancer patients receiving chemotherapy. Br J Nutr. 2013;109(5):894-7.
9)  Solheim TS et al. Weight loss, appetite loss and food intake in cancer patients with cancer cachexia: three peas in a pod? - analysis from a
multicenter cross sectional study. Acta Oncol. 2014;53(4):539-46.
10) Sánchez-Lara K et al. Effects of an oral nutritional supplement containing eicosapentaenoic acid on nutritional and clinical outcomes in patients with advanced non-small cell lung cancer: randomised trial. Clin Nutr. 2014;33(6):1017-23.
11) de van der Schueren MAE et al. Systematic review and meta-analysis of the evidence for oral nutritional intervention on nutritional and clinical outcomes during chemo(radio)therapy: current evidence and guidance for design of future trials. Ann Oncol. 2018;29(5):1141-53.
12) Shirai Y et al. Fish oil-enriched nutrition combined with systemic chemotherapy for gastrointestinal cancer patients with cancer cachexia. Sci Rep. 2017;7(1):4826.
13) van der Meij BS et al. Oral nutritional supplements containing (omega-3) polyunsaturated fatty acids affect the nutritional status of patients with stage III non-small cell lung cancer during multimodality treatment. J Nutr. 2010;140(10):1774-80.
14) van der Meij BS et al. Oral nutritional supplements containing omega-3 polyunsaturated fatty acids affect quality of life and functional status in lung cancer patients during multimodality treatment: an RCT. Eur J Clin Nutr. 2012;66(3):399-404.