Smart Protein Blending for Diverse Patient Needs

Fresubin^® tube feeds with Protein DUO^® support optimal protein utilisation across a wide range of clinical situations and feeding regimens.

Smart Protein Blending for Diverse Patient Needs

Why Protein Quality Matters as Much as Protein Quantity

Adequate protein provision in clinical nutrition is not simply a question of how much protein is delivered, but also how well it is absorbed, utilised, and timed relative to the patient's metabolic state, age, and clinical condition.

Protein DUO* is built on the principle that different clinical situations demand different patterns of amino acid availability, and that blending proteins with complementary digestion kinetics is a more precise approach than relying on a single protein source.

Complementary Digestion Kinetics

Combining rapidly digested whey-based and soy-based proteins with slow-digesting casein-based proteins enables both an immediate amino acid peak to stimulate muscle protein synthesis and a sustained release to help attenuate muscle protein breakdown.^1,2

Natural Casein Coagulation

When casein reaches the stomach, natural coagulation slows gastric emptying and extends amino acid availability over several hours.^1,2

High-Quality Protein Sources

High digestibility and absorption of whey-, soy- and casein-based proteins, with an essential amino acid profile rich in branched-chain amino acids, particularly leucine, to support activation of muscle protein synthesis. ^3,5,6

Matching Protein Kinetics to Individual Patient Requirements

No single protein blend is appropriate for every patient. The Protein Duo concept in Fresubin Standard Tube Feeds smartly blends casein-based proteins with whey- or soy-based proteins, adapted to adapted to the patient needs each product is intended to meet.

A patient speaks with a healthcare professional alongside Fresubin tube feeds with Protein DUO, which combine casein-based proteins with whey- or soy-based proteins to suit different patient needs.

How Protein DUO Compares to Hybrid Protein Blends

Not all protein blends deliver equal digestibility or amino acid bioavailability. The quality of a formula depends not on the number of protein sources but on how well the blend is optimised, ensuring complete amino acid coverage and efficient absorption to meet clinical nutritional goals.³

Laboratory analyses show that Fresubin® Energy with Protein DUO provides more than 20% higher levels of leucine and essential amino acids compared with an equivalent competitor product.¹ This nutritional advantage may be particularly relevant when supporting muscle protein synthesis, where an adequate supply of leucine and essential amino acids plays a key role.⁷

Fresubin® ONS

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Fresubin® Tube Feeds

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Protein DUO factsheets can be downloaded here:

Protein DUO

Filename: Fresubin_ProteinDUO_B_HCP_Jul2025.pdf
Size: 6 MB
Format: pdf

*Fresubin Protein DUO products are food for special medical purposes, to be used under medical supervision. For Healthcare Professionals only.

References:

¹Tang JE et al. J Appl Physiol (1985). 2009;107(3):987-92.
²Boirie Y et al. Proc Natl Acad Sci U S A. 1997;94(26):14930-5.
³Xu ZR et al. Br J Nutr. 2015;113(1):25-34.
⁴Herreman L et al. Food Sci Nutr. 2020;8(10):5379-5391.
⁵Mathai JK et al. Br J Nutr. 2017;117(4):490-499.
⁶Unpublished 2024. Independent laboratory analysis - Data on file.